NAD+ is involved in essential energy production and is central to aging and longevity. Declining levels of NAD+ accelerate the development of all hallmarks of aging, including DNA damage, mitochondrial dysfunction, stem cell exhaustion, and senescence. Inflammation is one of the main drivers of aging, and it leads to the depletion of NAD+ levels. When there is an increased level of inflammation, it increases biological aging, while higher levels of inflammation are increased when a person is getting older. A glycoprotein antibiotic called CD38 is one of the main consumers of NAD+, and with high levels of CD38, NAD+ levels will drop. High levels of inflammation chronically will continuously deplete a person's blood form of NAD+ and is caused by excessive exercise, even in healthy exercises such as resistance training and maximum intensity type of training that depletes NAD+ levels, while low-level cardiovascular exercise raises energy levels. Fatigue is also one of the signs of low NAD+ levels. When there is low NAD+, everything related to energy production such as mitochondrial function, brain function, muscle function, overall energy levels, and well-being is also affected.
Physical and aesthetic aging is a sign of how much oxidative stress a person's body is under, and the more oxidative stress a person experiences, the faster their energy levels are depleted. Wrinkle formation increases with aging and is caused by the deterioration of collagen structures, increased vulnerability to antioxidant stress, and not enough antioxidant defense systems to counteract the oxidative stress of being alive. The body uses NMN and NAD+ to buffer against the oxidative stress experienced during life, including UV radiation from the sun. Brain fog is also a sign of as the brain uses a lot of energy and cognitive dysfunction and cognitive decline are linked to lower energy levels. Metabolic syndrome is also linked to low NAD+ levels, which leads to hyperglycemia, elevated levels of triglycerides, elevated levels of cholesterol, elevated waist circumference, or obesity. These health conditions raise inflammation, which depletes NAD+ levels as the body has to use that NAD+ to counteract the inflammation. People who are obese lack energy and motivation, which may be their low levels of NAD+. To address these signs of low NAD+ levels, individuals may consider lifestyle changes such as losing weight, calorie restriction, and minimizing inflammation.
Michael Lickteig, along with his wife Melissa, built Liberty IV Infusion Therapy to serve the North Texas community. Both Michael and Melissa are Nationally Registered Paramedics licensed in the State of Texas, and both hold National Board Certification as Certified Flight Paramedics. Their careers in emergency medicine span more than a decade working in prehospital emergency 911 and critical care transport, as well as on staff inside some of North Texas’ busiest emergency/trauma units serving both adult and pediatric populations.. Michael holds an MBA from the University of North Texas and Melissa a BS degree from the University of Texas Arlington. The Lickteig family has strong ties to the military and has established partnerships with retired veterans and first responder organizations dedicated to reducing the occurrence of suicide in these vulnerable groups. Their goal is to make care available and affordable to veterans, first responders, or anyone else who is struggling with chronic pain, TBI, or PTSD throughout the North Texas Region.
Michael Lickteig NRP , LP, FP-C, MBA
Melissa Lickteig NRP, LP, FP-C, BS
Sobriety and Satiety: Is NAD+ the Answer?
NAD+ therapy in age-related degenerative disorders: A benefit/risk analysis
Clinical Evidence for Targeting NAD Therapeutically